Interferon Gamma-1b

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Interferon Gamma-1b

 Actions
 Indications
 Contraindications
 Route/Dosage
 Interactions
 Lab Test Interferences
 Adverse Reactions
 Precautions
Patient Care Considerations
 Administration/Storage
 Assessment/Interventions
 Patient/Family Education


(IN-ter-FEER-ahn GAM-uh-1b)
Actimmune
Injection: 100 mcg (2 million IU)/0.5 mL
Class: Interferon/Immunomodulator

 Actions Produces potent phagocyte-activating effects, including generation of toxic oxygen metabolites within phagocytes, which mediate killing of microorganisms. Activities include enhancement of oxidative metabolism of tissue macrophages and enhancement of antibody-dependent cellular cytotoxicity and natural killer (NK) cell activity.

 Indications Reduction of frequency and severity of serious infections associated with chronic granulomatous disease.

Treatment of small-cell lung cancer, atopic dermatitis, trauma-related infections, metastatic renal-cell carcinoma, cutaneous T-cell lymphoma, asthma and allergies, refractory leishmaniasis, chronic myelogenous leukemia, and AIDS.

 Contraindications Hypersensitivity to E. coli-derived products.

 Route/Dosage

ADULTS & CHILDREN: SC 50 mcg/m2 (1.5 million U/m2) if body surface area is > 0.5 m2 or 1.5 mcg/kg/dose if body surface area is £ 0.5 m2. Administer 3 times/wk (eg, Monday, Wednesday, Friday) into right or left deltoid or anterior thigh. If severe adverse reactions develop, reduced dosage or discontinuation of therapy may be necessary until those reactions subside.

 Interactions

Live virus vaccines (eg, measles, mumps, polio, rubella): May inhibit antibody response after immunization; avoid concurrent use. Myelosuppressive agents: Additive neutropenic effects are possible.

 Lab Test Interferences None well documented.

 Adverse Reactions

CNS: Decreased mental status; gait disturbance; dizziness; fatigue; headache. GI: Diarrhea; vomiting; nausea. GU: Proteinuria. HEMATOLOGIC: Thrombocytopenia. OTHER: Fever; chills; erythema or tenderness at injection site; myalgia; arthralgia.

 Precautions

Pregnancy: Category C. Lactation: Undetermined. Children: Safety and efficacy in children < 1 yr not established. Special risk patients: Exercise caution in patients with seizure disorders, compromised CNS function, cardiac disease, and myelosuppression.


PATIENT CARE CONSIDERATIONS


 Administration/Storage

 Assessment/Interventions

 Patient/Family Education

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Copyright
© 2003 Facts and Comparisons
David S. Tatro
A to Z Drug Facts

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